Di Felice's Group

Molecular anatomy and electron microscopy laboratory, bionec department, university of palermo, via del vespro 129, 90127 palermo, italy
Group Leader
Valentina Di Felice
Antonella Marino Gammazza (post-doc), Claudia Campanella (post-doc), Rosario Barone (post-doc), Patrizia Catanese (post-doc), Claudia Serradifalco (PhD student), Luigi Rizzuto (graduate student)
Scientific interests
Our research group is actually involved into several projects, here are listed the most important:
-       pre-clinical studies on PLA and fibrinoin scaffolds to be used in cardiac surgery to repair a damaged myocardium, in vivo differentiation of adult cardiac stem cells and new surgical approaches;
-       integrins as non-conventional receptors for the two peptides vasostatin-1 and catestatin, derived from the cleavage of the protein chromogranin A;
-       effects of CLA (conjugated linoleic acid) on the synthesis of testosterone on atletes and on R2C cells ( leydig cells);
-       Chlamydia trachomatis infections and their role in the carcerogenesis of the cervix, role of HSP60;
-       role of HSP60 in replicative senescence
The staff of our laboratory is expert in electron microscopy. In all papers microscopy is a leading technique.
relevant publications
1: Angelone T, Quintieri AM, Goumon Y, Di Felice V, Filice E, Gattuso A, Mazza R, Corti A, Tota B, Metz-Boutigue MH, Cerra MC. Cytoskeleton mediates negative inotropism and lusitropism of chromogranin A-derived peptides (human vasostatin1-78 and rat CgA(1-64)) in the rat heart. Regul Pept. 2009 Nov 5. [Epub ahead of print]
2: Di Felice V, Zummo G. Tetralogy of fallot as a model to study cardiac progenitor cell migration and differentiation during heart development. Trends Cardiovasc Med. 2009 May;19(4):130-5
3: Di Felice V, Ardizzone NM, De Luca A, Marciano’ V, Gammazza AM, Macaluso F, Manente L, Cappello F, De Luca A, Zummo G. OPLA scaffold, collagen I, and horse serum induce an higher degree of myogenic differentiation of adult rat cardiac stem cells. J Cell Physiol. 2009 Dec;221(3):729-39
4: Cappello F, Conway de Macario E, Di Felice V, Zummo G, Macario AJ. Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin. PLoS Pathog. 2009 Aug;5(8):e1000552. Epub 2009 Aug 28.
5: Di Felice V, De Luca A, Colorito ML, Montalbano A, Ardizzone NM, Macaluso F, Gammazza AM, Cappello F, Zummo G. Cardiac stem cell research: an elephant in the room? Anat Rec (Hoboken). 2009 Mar;292(3):449-54
Scientific instruments
JEOL Transmission Electron Microscope, JEOL Scanning Electron Microscope, LEICA Confocal Microscope, two cell culture rooms with microscopes and cameras, Biotechnology room for plasmids, Molecular biology room for proteins, Proteomic room, Ultramicrotome room, Immunohistochemistry room, electron micriscopy room. At Istituto Zooprofilattico Sperimentale della Sicilia there is an animal facility for small and medium size animals, a surgery room for small and medium size animals, and a patological anatomy facility.

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